yes it is possible..in material master say "workcenter detrmines backlfush" and put backlfush indicator in either workcenter or routing.
for example
m1
workcenter 1 - backflush indicator here
m1
workcenter 2 - no backflush indicator here
If wokcenter is same in your scenario, then add backflush in routing level and when you create production order, you need to select the routings or use different production versions